11/19/2022 0 Comments Cis 9 trans 11 uk![]() ![]() Neurofibrillary tangles, which are composed of hyperphosphorylated and aggregated tau in neurons, are another hallmark of AD however, they are thought to be secondary to amyloid pathology 1, 2. Although secreted Aβ40 is much more abundant than Aβ42, Aβ42 is considered to be the causative molecule for triggering the onset of AD because it is more prone to aggregation, more neurotoxic, and the major component in senile plaques 3, 4. The two most common isoforms of Aβ are 40 and 42 residues in length, depending on the site of γ-secretase cleavage 1. Aβ is generated from amyloid precursor protein (APP) through sequential cleavage by two proteases called β- and γ-secretases 1, 2. The pathological hallmarks of AD are extracellular senile plaques, which are composed of amyloid-β protein (Aβ), and neurofibrillary tangles 1, 2. Thus, dietary c-9, t-11-CLA entered the brain and appeared to exhibit beneficial effects on AD, including a decrease in Aβ levels and suppression of inflammation.Īlzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and cognitive dysfunction, and has risen in prevalence to an estimated 40 million patients worldwide 1, 2. In addition, liquid chromatography–tandem mass spectrometry (LC–MS/MS) and gas chromatographic analysis revealed that the levels of lysophosphatidylcholine (LPC) containing c-9, t-11-CLA (CLA-LPC) and free c-9, t-11-CLA were significantly increased in the brain of c-9, t-11-CLA diet-fed mice. We found that c-9, t-11-CLA diet-fed AD model mice significantly exhibited (1) a decrease in amyloid-β protein (Aβ) levels in the hippocampus, (2) an increase in the number of microglia, and (3) an increase in the number of astrocytes expressing the anti-inflammatory cytokines, interleukin-10 and 19 (IL-10, IL-19), with no change in the total number of astrocytes. In this study, we investigated the effect of dietary intake of c-9, t-11-CLA on the pathogenesis of an AD mouse model. However, the effects of c-9, t-11-CLA on Alzheimer’s disease (AD) remain to be elucidated. The predominant dietary CLA is cis-9, trans-11-CLA ( c-9, t-11-CLA), which constitutes up to ~ 90% of total CLA and is thought to be responsible for the positive health benefits associated with CLA. Conjugated linoleic acid (CLA) is an isomer of linoleic acid (LA). ![]()
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